Charging a new Brimstone laser removes the original from in front of the player, but not the additional ones added by Monstro's Lung. File:DLC Indicator.png Fires multiple Brimstone lasers in random directions around Isaac.Monstro's Lung: Overridden by Brimstone.File:Afterbirth† Indicator.png Jacob's Ladder: Overridden by Brimstone.Isaac's Tears: Fires normal tears, but nearly instantly charges when charging Brimstone.Isaac gains increased damage, decreased tears, and the poison effect. File:Afterbirth† Indicator.png Isaac shoots Ipecac tears while charging Brimstone.Ipecac: The character gains neither the increased damage nor the decreased tears of Ipecac.Hook Worm: Beam changes angles while firing straight, but also effectively increases the width of the beam.File:DLC Indicator.png Holy Light: Overridden by Brimstone.Fire Mind: Beam inflicts burning, but cannot cause explosions or leave fires on the ground.File:DLC Indicator.png Evil Eye: Overridden by Brimstone.Azazel's mini-brimstone does not give the Sad Bombs effect. File:DLC Indicator.png After the missile hits the ground, it spawns 10 Brimstone beams similar to the effect given by Sad Bombs.File:DLC Indicator.png Isaac shoots bombs while charging Brimstone.Cursed Eye: Brimstone overrides the burst shot effect but damage is increased.File:DLC Indicator.png Continuum: Overridden by Brimstone.Chocolate Milk: Decreases charge time slightly, but does not increase damage.This allows for a huge damage increase from longer distances. File:DLC Indicator.png Beam will gradually increase in size but rapidly increase damage the farther it travels, on a multiplier that is roughly +20% per tile of distance.A Lump of Coal: Changes the color, but does not have an effect on damage.
File:DLC Indicator.png 8 Inch Nails: Brimstone pushes enemies away in the direction the beam is travelling, but not out of the path of the beam.File:DLC Indicator.png Shoots two Brimstone lasers simultaneously without increasing charge time.On victory laps, if another Brimstone is picked up, then another beam is added.Without the long ranged version, his mini-brimstone will override any homing items. Picking up Brimstone with him will give him the long ranged version. Azazel starts the game with a short-ranged, slower charging version of Brimstone.Can only be fired after a short charge-up period. Tears are replaced by a charged blood laser beam that pierces through all enemies and obstacles in its path and deals high damage.
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